Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Acute traumatic spinal cord injury

I Eli, DP Lerner, Z Ghogawala - Neurologic clinics, 2021 - neurologic.theclinics.com
Acute traumatic spinal cord injury (SCI) is typically associated with devastating outcomes.
The injury to the spinal cord results in damage to motor, sensory, and autonomic functions of …

Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury

W Liu, Z Ma, J Li, X Kang - Stem cell research & therapy, 2021 - Springer
Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs
below the injured segment. SCI not only results in physical and psychological harm to …

Modern medical management of spinal cord injury

M Karsy, G Hawryluk - Current Neurology and Neuroscience Reports, 2019 - Springer
Abstract Purpose of Review Spinal cord injury (SCI) shows an incidence of 10.4–83
cases/million/year globally and remains a significant source of morbidity and cost to society …

Acute spinal cord injury: Pathophysiology and pharmacological intervention

Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Management of acute traumatic spinal cord injury: a review of the literature

TY Wang, C Park, H Zhang, S Rahimpour… - Frontiers in …, 2021 - frontiersin.org
Traumatic spinal cord injury (TSCI) is a debilitating disease that poses significant functional
and economic burden on both the individual and societal levels. Prognosis is dependent on …

Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury

JL Nielson, J Paquette, AW Liu, CF Guandique… - Nature …, 2015 - nature.com
Data-driven discovery in complex neurological disorders has potential to extract meaningful
syndromic knowledge from large, heterogeneous data sets to enhance potential for …

Spinal cord perfusion pressure predicts neurologic recovery in acute spinal cord injury

JW Squair, LM Bélanger, A Tsang, L Ritchie… - Neurology, 2017 - AAN Enterprises
Objective: To determine whether spinal cord perfusion pressure (SCPP) as measured with a
lumbar intrathecal catheter is a more predictive measure of neurologic outcome than the …

The impact of blood pressure management after spinal cord injury: a systematic review of the literature

YS Saadeh, BW Smith, JR Joseph, SY Jaffer… - Neurosurgical …, 2017 - thejns.org
OBJECTIVE Spinal cord injury (SCI) results in significant morbidity and mortality. Improving
neurological recovery by reducing secondary injury is a major principle in the management …