RNA modification m6Am: the role in cardiac biology

D Benak, F Kolar, L Zhang, Y Devaux, M Hlavackova - Epigenetics, 2023 - Taylor & Francis
Epitranscriptomic modifications have recently emerged into the spotlight of researchers due
to their vast regulatory effects on gene expression and thereby cellular physiology and …

The role of m6A and m6Am RNA modifications in the pathogenesis of diabetes mellitus

D Benak, S Benakova, L Plecita-Hlavata… - Frontiers in …, 2023 - frontiersin.org
The rapidly develo** research field of epitranscriptomics has recently emerged into the
spotlight of researchers due to its vast regulatory effects on gene expression and thereby …

Epitranscriptomic regulation in fasting hearts: implications for cardiac health

D Benak, K Holzerova, J Hrdlicka, F Kolar, M Olsen… - RNA biology, 2024 - Taylor & Francis
Cardiac tolerance to ischaemia can be increased by dietary interventions such as fasting,
which is associated with significant changes in myocardial gene expression. Among the …

[HTML][HTML] Sixty Years of Heart Research in the Institute of Physiology of the Czech Academy of Sciences

B Ošťádal, F Kolář - Physiological Research, 2024 - pmc.ncbi.nlm.nih.gov
In 2023 six decades have elapsed since the first experimental work on the heart muscle was
published, in which a member of the Institute of Physiology of the Czech Academy of …

[HTML][HTML] Epitranscriptomic regulations in the heart

D Benak, F Kolar, M Hlavackova - Physiological Research, 2024 - pmc.ncbi.nlm.nih.gov
RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay,
and translation. Epitranscriptomic regulations therefore significantly influence cellular …

FTO in health and disease

D Benak, A Sevcikova, K Holzerova… - Frontiers in Cell and …, 2024 - frontiersin.org
Fat mass and obesity-associated (FTO) protein, a key enzyme integral to the dynamic
regulation of epitranscriptomic modifications in RNAs, significantly influences crucial RNA …

Unveiling the proteome of the fasting heart: Insights into HIF-1 pathway regulation

D Benak, K Holzerova, F Kolar, M Chalupova… - Frontiers in …, 2024 - frontiersin.org
Fasting is a common dietary intervention known for its protective effects against metabolic
and cardiovascular diseases. While its effects are mostly systemic, understanding tissue …

Coding Hypertension by Nicotine: Unraveling the Sex-Specific Role Of m6A Demethylase for NOX2 RNA-Protein Connection

T Münzel, O Hahad, A Daiber - Hypertension, 2024 - Am Heart Assoc
Smoking and va** represent major health threats, 1 and tobacco smoking is among the
top 5 contributors to the global disease burden. 2 According to a World Health Organization …

Epitranscriptomics and cardioprotective interventions

D Benák - 2024 - dspace.cuni.cz
1 Ischemic heart disease stands as the foremost global cause of mortality. Myocardial
ischemia results in damage to cardiomyocytes which can further lead to impaired heart …