The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

Purpose: To investigate the expression of humanin (HN) in human retinal pigment epithelial
(hRPE) cells and its effect on oxidative stress–induced cell death, mitochondrial …

Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of
the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles …

The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected
domains surrounding cone and rod photoreceptor cells and extends throughout the …

αB Crystallin is a chaperone protein with anti-apoptotic and anti-inflammatory functions and
has been identified as a biomarker in age-related macular degeneration. The purpose of this …

Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a
major cause of vision loss. However, the mechanisms underlying their progression remain ill …

The polarized phenotype of the retinal pigment epithelium is crucial for the outer retina-
blood barrier and support of photoreceptors and underlying choroid, and its disruption plays …

Replacing defective retinal pigment epithelial (RPE) cells with those derived from human
embryonic stem cells (hESCs) or human-induced pluripotent stem cells (hiPSCs) is a …