Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy.
Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) …

Cancer development requires the acquisition of several capabilities that include increased
replicative potential, anchorage and growth-factor independence, evasion of apoptosis …

How intracellular cytoskeletal and signaling proteins connect and communicate with the
extracellular matrix (ECM) is a fundamental question in cell biology. Recent biochemical …

Integrin-associated signalling renders cells more resistant to genotoxic anti-cancer agents
like ionizing radiation and chemotherapeutic substances, a phenomenon termed cell …

Despite evidence demonstrating the role of β1-integrin in the regulation of cancer cell
proliferation in vitro, the importance of this cell adhesion receptor during the initiation and …

The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed
cell death by phosphorylating substrates that regulate both apoptosis and cellular …

Anoikis is a unique mode of apoptotic cell death that occurs consequentially to insufficient
cell-matrix interactions. Resistance to anoikis is a critical contributor to tumor invasion and …

Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions
and regulates many cellular processes, including growth, proliferation, survival …

Current evidence highlights the ability of adaptor (or scaffold) proteins to create signalling
platforms that drive cellular transformation upon integrin-dependent adhesion and growth …

The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway is activated downstream of a variety
of extracellular signals and activation of this signaling pathway impacts a number of cellular …