It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …

Sleep disturbance is increasingly recognized as an important, but understudied, mechanism
in the complex and multi-factorial causation of the symptoms and functional disability …

It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as the
central circadian clock and 25 years since the last overview of developments in the field was …

The primary mammalian circadian clock resides in the suprachiasmatic nucleus (SCN), a
recipient of dense retinohypothalamic innervation. In its most basic form, the circadian …

Major depression is one of the leading causes of premature death and disability. Although
available drugs are effective, they also have substantial limitations. Recent advances in our …

Adolescents and young adults are often excessively sleepy. This excessive sleepiness can
have a profound negative effect on school performance, cognitive function, and mood and …

The circadian clock in the suprachiasmatic nucleus (SCN) is thought to drive daily rhythms of
behavior by secreting factors that act locally within the hypothalamus. In a systematic screen …

Although the circadian time-kee** properties of the suprachiasmatic nuclei (SCN) require
gene expression, little is known about the signal transduction pathways that initiate …

The mammalian circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN),
has two subdivisions. The core is located above the optic chiasm, receives primary and …

Using microdialysis, we investigated the circadian rhythms of the extracellular
concentrations of dopamine, glutamate and γ‐aminobutyric acid (GABA) in the striatum and …