Target-identification and mechanism-of-action studies have important roles in small-
molecule probe and drug discovery. Biological and technological advances have resulted in …

This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

THE immunosuppressive drugs cyclosporin A (CsA) and FKS06 both interfere with a Ca2+-
sensitive T-cell signal transduction pathway1–4thereby preventing the activation of specific …

Dimerization and oligomerization are general biological control mechanisms contributing to
the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and …

Sirolimus is the USAN-assigned generic name for the natural product rapamycin. Sirolimus
is produced by a strain of Streptomyces hygroscopicus, isolated from a soil sample collected …

The yeast TOR2 gene encodes an essential 282 kd phosphatidylinositol (PI) 3-kinase
homolog. TOR2 is related to the catalytic subunit of bovine PI 3-kinase and to yeast VPS34 …

Garlic is one of the most widely employed condiments in cooking. It has also been used
since ancient times in traditional plant-based medicine, largely based on its organosulfur …

Brain ischemia and reperfusion engage multiple independently-fatal terminal pathways
involving loss of membrane integrity in partitioning ions, progressive proteolysis, and …

Abstract Summary Cyclophilins (Enzyme Commission (EC) number 5.1. 2.8) belong to a
group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are …

Retroviral Gag protein is capable of directing the assembly of virion particles independent of
other retroviral elements and plays an important role early in the infection of a ceil. Using the …