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Trials and tribulations of MicroRNA therapeutics
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …
particularly various cancer types, has generated significant interest in exploring their …
Lost in translation: the valley of death across preclinical and clinical divide–identification of problems and overcoming obstacles
A rift that has opened up between basic research (bench) and clinical research and patients
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …
Extracellular vesicles and their emerging roles as cellular messengers in endocrinology: an endocrine society scientific statement
During the last decade, there has been great interest in elucidating the biological role of
extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell …
extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell …
Effect of exercise training before and after bariatric surgery: A systematic review and meta‐analysis
We aimed to assess the effectiveness of exercise training programs in adults with severe
obesity undergoing bariatric surgery. A systematic search of controlled trials published up to …
obesity undergoing bariatric surgery. A systematic search of controlled trials published up to …
Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Healthcare is undergoing a transformation, and it is imperative to leverage new technologies
to generate new data and support the advent of precision medicine (PM). Recent scientific …
to generate new data and support the advent of precision medicine (PM). Recent scientific …
[HTML][HTML] Circulating microRNAs as potential biomarkers in pancreatic cancer—advances and challenges
There is an urgent unmet need for robust and reliable biomarkers for early diagnosis,
prognosis, and prediction of response to specific treatments of many aggressive and deadly …
prognosis, and prediction of response to specific treatments of many aggressive and deadly …
MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets
Obesity is a metabolic condition usually accompanied by insulin resistance (IR), type 2
diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation …
diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation …
Circulating liquid biopsy biomarkers in Glioblastoma: advances and challenges
Gliomas, particularly glioblastoma (GBM), represent the most prevalent and aggressive
tumors of the central nervous system (CNS). Despite recent treatment advancements, patient …
tumors of the central nervous system (CNS). Despite recent treatment advancements, patient …
A unique plasma microRNA profile defines type 2 diabetes progression
A major unmet medical need to better manage Type 2 Diabetes (T2D) is the accurate
disease prediction in subjects who show glucose dysmetabolism, but are not yet diagnosed …
disease prediction in subjects who show glucose dysmetabolism, but are not yet diagnosed …
Does intensive multidisciplinary intervention for adults who elect bariatric surgery improve post‐operative weight loss, co‐morbidities, and quality of life? A systematic …
This systematic review and meta‐analysis of intervention studies aims to evaluate the effect
of preoperative and/or post‐operative support for adults who elect bariatric surgery delivered …
of preoperative and/or post‐operative support for adults who elect bariatric surgery delivered …