Applications of fluorine in medicinal chemistry
EP Gillis, KJ Eastman, MD Hill… - Journal of medicinal …, 2015 - ACS Publications
The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …
about the unique properties associated with this unusual element and how to deploy it with …
Radiochemistry for positron emission tomography
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …
Introduction of fluorine and fluorine‐containing functional groups
T Liang, CN Neumann, T Ritter - … Chemie International Edition, 2013 - Wiley Online Library
Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …
were enabled most prominently by organo‐and transition‐metal catalysis. The most …
Monofluorination of organic compounds: 10 years of innovation
Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …
to the monofluorination of organic compounds, ie, synthetic methods allowing the …
18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography
S Preshlock, M Tredwell, V Gouverneur - Chemical reviews, 2016 - ACS Publications
Diverse radiochemistry is an essential component of nuclear medicine; this includes
imaging techniques such as positron emission tomography (PET). As such, PET can track …
imaging techniques such as positron emission tomography (PET). As such, PET can track …
Self‐protective room‐temperature phosphorescence of fluorine and nitrogen codoped carbon dots
The unstable triplet excited state is a core problem when develo** self‐protective room
temperature phosphorescence (RTP) in carbon dots (CDs). Here, fluorine and nitrogen …
temperature phosphorescence (RTP) in carbon dots (CDs). Here, fluorine and nitrogen …
Modern carbon–fluorine bond forming reactions for aryl fluoride synthesis
MG Campbell, T Ritter - Chemical Reviews, 2015 - ACS Publications
In recent years, there has been a dramatic increase in available methods for the installation
of fluorine and fluorine-containing functional groups in organic molecules, 1− 4 and the …
of fluorine and fluorine-containing functional groups in organic molecules, 1− 4 and the …
Molecular imaging with PET
SM Ametamey, M Honer, PA Schubiger - Chemical reviews, 2008 - ACS Publications
Recent advances in noninvasive imaging modalities have opened endless opportunities for
molecular diagnostic and therapeutic procedures. The term “molecular imaging” is broadly …
molecular diagnostic and therapeutic procedures. The term “molecular imaging” is broadly …
Fluorine-18 radiochemistry, labeling strategies and synthetic routes
Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET)
radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear …
radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear …
Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography
Positron emission tomography (PET) is a powerful and rapidly develo** area of molecular
imaging that is used to study and visualize human physiology by the detection of positron …
imaging that is used to study and visualize human physiology by the detection of positron …