Postnatal brain development is studded with sensitive periods during which experience
dependent plasticity is enhanced. This enables rapid learning from environmental inputs …

Striatal dopamine (DA) is thought to code for learned associations between cues and
reinforcers and to mediate approach behavior toward a reward. Less is known about the …

The vast majority of drugs entering human trials fail. This problem (called “attrition”) is widely
recognized as a public health crisis, and has been discussed openly for the last two …

Comprehensive behavioral analyses of transgenic and knockout mice have successfully
identified the functional roles of many genes in the brain. Over the past 10 years, strategies …

The neurodevelopmental hypothesis of schizophrenia has been highly influential in sha**
our current thinking about modeling the disease in animals. Based on the findings provided …

Human epidemiological studies have provided compelling evidence that the risk of
develo** schizophrenia is significantly enhanced following prenatal and/or perinatal …

Although sensitizing processes occur earlier, schizophrenia is diagnosed in young
adulthood, which suggests that it might involve a pathological transition during late brain …

Many neuropsychiatric diseases are associated with cognitive rigidity linked to prefrontal
dysfunction. For example, schizophrenia and Parkinson's disease are associated with …

Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate
with functional outcome, and are not well treated with current antipsychotic therapies. In …

'Learning to learn'phenomena have been widely investigated in cognition, perception and
more recently also in action. During concept learning tasks, for example, it has been …