Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and
protein expression, point to biological functions and molecular pathways being deregulated …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs)
occurs across a broad set of systems and is reported to be upregulated in cancer, where it …

Integrin adhesions are a structurally and functionally diverse family of transmembrane, multi-
protein complexes that link the intracellular cytoskeleton to the extracellular matrix (ECM) …

Remodeling of extracellular matrix (ECM) is a fundamental cell property that allows cells to
alter their microenvironment and move through tissues. Invadopodia and podosomes are …

Background Tks5 regulates invadopodium formation, but the precise timing during
invadopodium lifetime (initiation, stabilization, maturation) when Tks5 plays a role is not …

Tumors are composed of heterogeneous phenotypes, each having different sensitivities to
the microenvironment. One microenvironment characteristic–matrix stiffness–helps to …

Matrix-activated integrins can form different adhesion structures. We report that
nontransformed fibroblasts develop podosome-like adhesions when spread on fluid Arg-Gly …

Though critical to normal development and cancer metastasis, how cells traverse basement
membranes is poorly understood. A central impediment has been the challenge of …

Background Metastasis is the leading cause of cancer mortality and is a major hurdle for
lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a …