Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for
degradation through autophagy. Here, we focus on two autophagic pathways, the …

The production of reactive species is an inevitable by-product of metabolism and thus, life
itself. Since reactive species are able to damage cellular structures, especially proteins, as …

Proteostasis, the controlled balance of protein synthesis, folding, assembly, trafficking and
degradation, is a paramount necessity for cell homeostasis. Impaired proteostasis is a …

Protein homeostasis (proteostasis) is an essential pillar for correct cellular function.
Impairments in proteostasis are encountered both in aging and in several human disease …