Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

In eukaryotic cells, macromolecular homeostasis requires selective degradation of damaged
units by the ubiquitin-proteasome system (UPS) and autophagy. Thus, dysfunctional …

Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Ferroptosis, a programmed cell death, has been identified and associated with cancer and
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …

The initiation and execution of cell death can be regulated by various lipids. How the levels
of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We …