[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation
Abstract Careaga MBL, Girardi CEN, Suchecki D. Understanding posttraumatic stress
disorder through fear conditioning, extinction and reconsolidation. NEUROSCI BIOBEHAV …
disorder through fear conditioning, extinction and reconsolidation. NEUROSCI BIOBEHAV …
Brain sites involved in fear memory reconsolidation and extinction of rodents
E Baldi, C Bucherelli - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
Fear memory is a motivational system essential for organisms survival having a central role
in organization of defensive behaviors to threat. In the last years there has been a growing …
in organization of defensive behaviors to threat. In the last years there has been a growing …
Modulation of the extinction of two different fear-motivated tasks in three distinct brain areas
NG Fiorenza, J Rosa, I Izquierdo, JC Myskiw - Behavioural brain research, 2012 - Elsevier
The hippocampus, basolateral amygdala and ventromedial prefrontal cortex participate in
the extinction of inhibitory avoidance and contextual fear conditioning. We studied the effect …
the extinction of inhibitory avoidance and contextual fear conditioning. We studied the effect …
Modulation of fear extinction by stress, stress hormones and estradiol: a review
U Stockhorst, MI Antov - Frontiers in behavioral neuroscience, 2016 - frontiersin.org
Fear acquisition and extinction are valid models for the etiology and treatment of anxiety,
trauma-and stressor-related disorders. These disorders are assumed to involve aversive …
trauma-and stressor-related disorders. These disorders are assumed to involve aversive …
Oxytocinergic manipulations in corticolimbic circuit differentially affect fear acquisition and extinction
N Lahoud, M Maroun - Psychoneuroendocrinology, 2013 - Elsevier
The oxytocinergic system promotes social behavior and reduces anxiety. The significant
roles and functional interactions of the medial prefrontal cortex and the amygdala in the …
roles and functional interactions of the medial prefrontal cortex and the amygdala in the …
Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons
M Maroun, PJ Ioannides, KL Bergman… - European Journal of …, 2013 - Wiley Online Library
Stress‐sensitive psychopathologies such as post‐traumatic stress disorder are
characterized by deficits in fear extinction and dysfunction of corticolimbic circuits mediating …
characterized by deficits in fear extinction and dysfunction of corticolimbic circuits mediating …
The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus
J Burgdorf, XL Zhang, C Weiss, A Gross, SR Boikess… - Neuroscience, 2015 - Elsevier
Abstract Rapastinel (GLYX-13) is an N-methyl-d-aspartate receptor (NMDAR) modulator that
has characteristics of a glycine site partial agonist. Rapastinel is a robust cognitive enhancer …
has characteristics of a glycine site partial agonist. Rapastinel is a robust cognitive enhancer …
Learning-induced changes in mPFC–BLA connections after fear conditioning, extinction, and reinstatement of fear
RM Vouimba, M Maroun - Neuropsychopharmacology, 2011 - nature.com
The neural circuit linking the medial prefrontal cortex (mPFC) and the basolateral amygdala
(BLA) has crucial roles in both the acquisition and the extinction of fear. However, the …
(BLA) has crucial roles in both the acquisition and the extinction of fear. However, the …
Enhanced extinction of aversive memories by high-frequency stimulation of the rat infralimbic cortex
Electrical stimulation of the rodent medial prefrontal cortex (mPFC), including the infralimbic
cortex (IL), immediately prior to or during fear extinction training facilitates extinction …
cortex (IL), immediately prior to or during fear extinction training facilitates extinction …