The mammalian circadian timing system: organization and coordination of central and peripheral clocks
Most physiology and behavior of mammalian organisms follow daily oscillations. These
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Circadian cycles affect a variety of physiological processes, and disruptions of normal
circadian biology therefore have the potential to influence a range of disease-related …
circadian biology therefore have the potential to influence a range of disease-related …
Genetics of circadian rhythms in Mammalian model organisms
PL Lowrey, JS Takahashi - Advances in genetics, 2011 - Elsevier
The mammalian circadian system is a complex hierarchical temporal network which is
organized around an ensemble of uniquely coupled cells comprising the principal circadian …
organized around an ensemble of uniquely coupled cells comprising the principal circadian …
Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm
The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a
network structure composed of multiple types of neurons. Here, we report that mice with a …
network structure composed of multiple types of neurons. Here, we report that mice with a …
Melatonin is required for the circadian regulation of sleep
AV Gandhi, EA Mosser, G Oikonomou, DA Prober - Neuron, 2015 - cell.com
Sleep is an evolutionarily conserved behavioral state whose regulation is poorly
understood. A classical model posits that sleep is regulated by homeostatic and circadian …
understood. A classical model posits that sleep is regulated by homeostatic and circadian …
Single‐cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin‐driven circadian network
Circadian rhythms in mammals are governed by the hypothalamic suprachiasmatic nucleus
(SCN), in which 20,000 clock cells are connected together into a powerful time‐kee** …
(SCN), in which 20,000 clock cells are connected together into a powerful time‐kee** …
Circadian clocks: regulators of endocrine and metabolic rhythms
Daily and seasonal rhythms in the endocrine system are co-ordinated by a hypothalamic
pacemaker, the suprachiasmatic nuclei (SCN) that is synchronised to solar time by direct …
pacemaker, the suprachiasmatic nuclei (SCN) that is synchronised to solar time by direct …
Circadian clocks and metabolism
Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and
metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals …
metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals …
Coupled network of the circadian clocks: a driving force of rhythmic physiology
The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …
beings, including humans, to anticipate and adapt to daily changes in their environment. In …
Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?
C Guilding, HD Piggins - European Journal of Neuroscience, 2007 - Wiley Online Library
The suprachiasmatic nucleus of the hypothalamus (SCN) is the master circadian pacemaker
or clock in the mammalian brain. Canonical theory holds that the output from this single …
or clock in the mammalian brain. Canonical theory holds that the output from this single …