Current status on development of steroids as anticancer agents
A Gupta, BS Kumar, AS Negi - The Journal of steroid biochemistry and …, 2013 - Elsevier
Steroids are important biodynamic agents. Their affinities for various nuclear receptors have
been an interesting feature to utilize them for drug development particularly for receptor …
been an interesting feature to utilize them for drug development particularly for receptor …
A review of biologically active oxime ethers
Oxime ethers are a class of compounds containing the> C= NOR moiety. The presence of
this moiety affects the biological activity of the compounds. In this review, the structures of …
this moiety affects the biological activity of the compounds. In this review, the structures of …
Synthesis of steroidal dihydropyrazole derivatives using green ZnO NPs and evaluation of their anticancer and antioxidant activity
Abstract Zinc oxide nanoparticles (ZnO NPs) were synthesized by a green method using
Azadirachta indica leaf extract. The structure of the prepared ZnO (NPs) were characterized …
Azadirachta indica leaf extract. The structure of the prepared ZnO (NPs) were characterized …
Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability
A series of new β-carboline-dithiocarbamate derivatives bearing phenyl, dithiocarbamate
and H/methyl substitutions at position-1, 3 and 9, respectively, were designed and …
and H/methyl substitutions at position-1, 3 and 9, respectively, were designed and …
4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer
Topoisomerases (topo-I and topo-II) have occupied a significant role in DNA replication,
transcription, and are a promising set of antitumor targets. In the present approach, a series …
transcription, and are a promising set of antitumor targets. In the present approach, a series …
Design and synthesis of imidazo [2, 1-b] thiazole linked triazole conjugates: Microtubule-destabilizing agents
Abstract A series of imidazo [2, 1-b] thiazole linked triazole conjugates were synthesized by
using Huisgen 1, 3-dipolar cyclo-addition reaction (click chemistry approach) and evaluated …
using Huisgen 1, 3-dipolar cyclo-addition reaction (click chemistry approach) and evaluated …
Design, synthesis, and antitumor activity evaluation of steroidal oximes
AR Gomes, AS Pires, AM Abrantes… - Bioorganic & medicinal …, 2021 - Elsevier
Steroidal compounds were proven to be efficient drugs against several types of cancer.
Oximes are also chemical structures frequently associated with anticancer activity. The main …
Oximes are also chemical structures frequently associated with anticancer activity. The main …
Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and …
AVS Rao, K Swapna, SP Shaik, VL Nayak… - Bioorganic & Medicinal …, 2017 - Elsevier
A series of colchicine site binding tubulin inhibitors were synthesized by the modification of
the combretastatin pharmacophore. The ring B was replaced by the pharmacologically …
the combretastatin pharmacophore. The ring B was replaced by the pharmacologically …
New selenosteroids as antiproliferative agents
A Fuentes-Aguilar, LL Romero-Hernández… - Organic & …, 2017 - pubs.rsc.org
Starting from natural steroids (diosgenin, hecogenin, smilagenin, estrone), we have
prepared a wide panel of selenoderivatives, including benzoselenazolones …
prepared a wide panel of selenoderivatives, including benzoselenazolones …
Steroidal oximes: Useful compounds with antitumor activities
Background: Steroids play an important role in life because they can regulate a variety of
biological processes and have been widely used in medicine namely as antiinflammatory …
biological processes and have been widely used in medicine namely as antiinflammatory …