Cardiac and neuronal HCN channelopathies
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease
The funny current, I f, was first recorded in the heart 40 or more years ago by Dario
DiFrancesco and others. Since then, we have learnt that I f plays an important role in …
DiFrancesco and others. Since then, we have learnt that I f plays an important role in …
Cellular and molecular mechanisms of functional hierarchy of pacemaker clusters in the sinoatrial node: new insights into sick sinus syndrome
The sinoatrial node (SAN), the primary pacemaker of the heart, consists of a heterogeneous
population of specialized cardiac myocytes that can spontaneously produce action …
population of specialized cardiac myocytes that can spontaneously produce action …
Bioengineering the cardiac conduction system: advances in cellular, gene, and tissue engineering for heart rhythm regeneration
N Naumova, L Iop - Frontiers in Bioengineering and Biotechnology, 2021 - frontiersin.org
Heart rhythm disturbances caused by different etiologies may affect pediatric and adult
patients with life-threatening consequences. When pharmacological therapy is ineffective in …
patients with life-threatening consequences. When pharmacological therapy is ineffective in …
Cardiac pacemaker dysfunction arising from different studies of ion channel remodeling in the aging rat heart
The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age,
resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults. The …
resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults. The …
A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies
Zebrafish and their mutant lines have been extensively used in cardiovascular studies. In the
current study, the novel system, Zebra II, is presented for prolonged electrocardiogram …
current study, the novel system, Zebra II, is presented for prolonged electrocardiogram …
[HTML][HTML] Regulation of cardiac ion channels by transcription factors: Looking for new opportunities of druggable targets for the treatment of arrhythmias
T Crespo-García, A Cámara-Checa, M Dago… - Biochemical …, 2022 - Elsevier
Cardiac electrical activity is governed by different ion channels that generate action
potentials. Acquired or inherited abnormalities in the expression and/or function of ion …
potentials. Acquired or inherited abnormalities in the expression and/or function of ion …
The Cardiac Pacemaker Story—Fundamental Role of the Na+/Ca2+ Exchanger in Spontaneous Automaticity
The electrophysiological mechanism of the sinus node automaticity was previously
considered exclusively regulated by the so-called “funny current”. However, parallel …
considered exclusively regulated by the so-called “funny current”. However, parallel …
Pacemaker Channels and the Chronotropic Response in Health and Disease
Loss or dysregulation of the normally precise control of heart rate via the autonomic nervous
system plays a critical role during the development and progression of cardiovascular …
system plays a critical role during the development and progression of cardiovascular …
Tbx18 promoted the conversion of human‐induced pluripotent stem cell‐derived cardiomyocytes into sinoatrial node‐like pacemaker cells
W Zhang, H Zhao, D Quan, Y Tang… - Cell Biology …, 2022 - Wiley Online Library
Sinoatrial node (SAN) pacemaker cells originate from T‐box transcription factor 18 (Tbx18)‐
expressing progenitor cells. The present study aimed to investigate whether overexpression …
expressing progenitor cells. The present study aimed to investigate whether overexpression …