Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …

A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …

Cannabinoids, when co-administered with opioids, may enable reduced opioid doses
without loss of analgesic efficacy (ie, an opioid-sparing effect). The aim of this study was to …

Cannabinoid co-administration may enable reduced opioid doses for analgesia. This
updated systematic review on the opioid-sparing effects of cannabinoids considered …

Background Approximately 18% of patients with cancer use cannabis at one time as
palliation or treatment for their cancer. We performed a systematic review of randomized …

Since antiquity, Cannabis has provoked enormous intrigue for its potential medicinal
properties as well as for its unique pharmacological effects. The elucidation of its major …

Cannabinoids combined with opioids produce synergistic antinociceptive effects,
decreasing the lowest effective antinociceptive opioid dose (ie, opioid-sparing effects) in …

This Phase II study evaluated analgesia, abuse liability, and cognitive performance of
hydromorphone and oral delta-9-tetrahydrocannabinol (THC; dronabinol) using a within …

Growing nonmedical use of prescription opioids is a global problem, motivating research on
ways to reduce use and combat addiction. Medical cannabis (“medical marijuana”) …

Cannabinoid receptor agonists, such as Δ 9-tetrahydrocannabinol (Δ 9-THC), enhance the
antinociceptive effects of μ-opioid receptor agonists, which suggests that combining …