Proteasomes are highly conserved multienzyme complexes responsible for proteolytic
degradation of the short-lived, regulatory, misfolded, and damaged proteins. They play an …

Radiation-induced enteritis, a significant concern in abdominal radiation therapy, is
associated closely with gut microbiota dysbiosis. The mucus layer plays a pivotal role in …

ABSTRACT PA28γ is a proteasomal interactor whose main and most known function is to
stimulate the hydrolytic activity of the 20S proteasome independently of ubiquitin and ATP …

Excess abdominal fat is a sexually dimorphic risk factor for cardio-metabolic disease and is
approximated by the waist-to-hip ratio adjusted for body mass index (WHRadjBMI). Whereas …

The search for novel tumor biomarkers and targets is of significant importance for the early
clinical diagnosis and treatment of Hepatocellular Carcinoma (HCC). The mechanisms by …

The thymus is the key immune organ for the development of T cells. Different populations of
thymic stromal cells interact with T cells, thereby controlling the dynamic development of T …

Pyroptosis, a typical inflammatory cell death mode, has been increasingly demonstrated to
have therapeutic value in inflammatory diseases such as sepsis. However, the mechanisms …

BACKGROUND Excess fat in the abdomen is a sexually dimorphic risk factor for cardio-
metabolic disease. The relative storage between abdominal and lower-body subcutaneous …

Human cytomegalovirus (HCMV) is a member of the beta herpesvirus family. HCMV has the
largest genome among herpesviruses at 235 kbp, encoding for hundreds of viral proteins. It …

Background Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma
(NHL). REGγ is important for tumor occurrence and development, but understanding of the …