A single-cell molecular map of mouse gastrulation and early organogenesis
Across the animal kingdom, gastrulation represents a key developmental event during which
embryonic pluripotent cells diversify into lineage-specific precursors that will generate the …
embryonic pluripotent cells diversify into lineage-specific precursors that will generate the …
[HTML][HTML] Induction and specification of cranial placodes
G Schlosser - Developmental biology, 2006 - Elsevier
Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …
Obesity-associated variants within FTO form long-range functional connections with IRX3
Genome-wide association studies (GWAS) have reproducibly associated variants within
introns of FTO with increased risk for obesity and type 2 diabetes (T2D),,. Although the …
introns of FTO with increased risk for obesity and type 2 diabetes (T2D),,. Although the …
The Iroquois family of genes: from body building to neural patterning
F Cavodeassi, J Modolell, JL Gómez-Skarmeta - 2001 - journals.biologists.com
The Iroquois (Iro) family of genes are found in nematodes, insects and vertebrates. They
usually occur in one or two genomic clusters of three genes each and encode transcriptional …
usually occur in one or two genomic clusters of three genes each and encode transcriptional …
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling
P Reinhardt, M Glatza, K Hemmer, Y Tsytsyura… - PloS one, 2013 - journals.plos.org
Phenotypic drug discovery requires billions of cells for high-throughput screening (HTS)
campaigns. Because up to several million different small molecules will be tested in a single …
campaigns. Because up to several million different small molecules will be tested in a single …
Brain-wide correspondence of neuronal epigenomics and distant projections
Single-cell analyses parse the brain's billions of neurons into thousands of 'cell-type'clusters
residing in different brain structures. Many cell types mediate their functions through targeted …
residing in different brain structures. Many cell types mediate their functions through targeted …
Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
The chromatin landscape of human brain cells encompasses key information to
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …
The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm
The murine Foxf1 gene encodes a forkhead transcription factor expressed in extra-
embryonic and lateral plate mesoderm and later in splanchnic mesenchyme surrounding the …
embryonic and lateral plate mesoderm and later in splanchnic mesenchyme surrounding the …
Identification and massively parallel characterization of regulatory elements driving neural induction
Epigenomic regulation and lineage-specific gene expression act in concert to drive cellular
differentiation, but the temporal interplay between these processes is largely unknown …
differentiation, but the temporal interplay between these processes is largely unknown …
Domain disruption and mutation of the bZIP transcription factor, MAF,associated with cataract, ocular anterior segment dysgenesis and coloboma
RV Jamieson, R Perveen, B Kerr… - Human molecular …, 2002 - academic.oup.com
Human congenital cataract and ocular anterior segment dysgenesis both demonstrate
extensive genetic and phenotypic heterogeneity. We identified a family where ocular …
extensive genetic and phenotypic heterogeneity. We identified a family where ocular …