Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox
system, encompassing pro-oxidative proteins and antioxidative proteins. These proteins …

The E2F transcription factor family, whose members are encoded by the E2F1-E2F8 genes,
plays pivotal roles in the cell cycle, apoptosis, metabolism, stemness, metastasis, aging …

Post-translational modifications of proteins play a pivotal role in both the initiation and
progression of ovarian cancer. Despite the recognition of USP33 as a significant factor in …

Immune checkpoint inhibitors, particularly PD-1/PD-L1 blockades, have been approved for
unresectable hepatocellular carcinoma (HCC). However, high resistance rates still limit their …

Background Long-term accumulation of misfolded proteins leads to endoplasmic reticulum
(ER) stress in colorectal cancer (CRC). However, the precise pathways controlling the …

Colorectal cancer (CRC) stands as the second most common cause of cancer-related
mortality globally and p53, a widely recognized tumor suppressor, contributes to the …

Lenvatinib is a targeted drug used for first-line treatment of hepatocellular carcinoma (HCC).
A deeper insight into the resistance mechanism of HCC against lenvatinib is urgently …

Gastric cancer (GC) presents a formidable global health challenge, and conventional
therapies face efficacy limitations. Ubiquitin‐specific protease 7 (USP7) plays pivotal roles in …

Background The typical pathological feature of pancreatic ductal adenocarcinoma (PDAC) is
a significant increase in stromal reaction, leading to a hypoxic and poorly vascularized tumor …

Metabolic rewiring has been recognized as a hallmark of malignant transformation,
supplying the biosynthetic and energetic demands for rapid cancer cell proliferation and …