RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …

Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …

▪ Abstract ADARs are RNA editing enzymes that target double-stranded regions of nuclear-
encoded RNA and viral RNA. These enzymes are particularly abundant in the nervous …

The NS1 protein of influenza A virus (NS1A protein) is a multifunctional protein that counters
cellular antiviral activities and is a virulence factor. Its N-terminal RNA-binding domain binds …

The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65–70
amino acids adopting an αβββα fold, whose central property is to bind to double-stranded …

Abstract mRNA localization is a common mechanism for targeting proteins to regions of the
cell where they are required. It has an essential role in localizing cytoplasmic determinants …

RNA silencing (also known as RNA interference) is a conserved biological response to
double-stranded RNA that regulates gene expression, and has evolved in plants as a …

Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of
establishing spatially restricted protein synthesis. The characterization of cis-acting signals …

RNA molecules face difficulties when folding into their native structures. In the cell, proteins
can assist RNAs in reaching their functionally active states by binding and stabilizing a …