Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic
development, injury repair and the pathogenesis of human diseases. In vertebrates, low …

INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

The prostate gland consists of basal and luminal cells arranged as pseudostratified
epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate …

Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell
proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can …

Abstract 30 years after the identification of WNTs, their signal transduction has become
increasingly complex, with the discovery of more than 15 receptors and co-receptors in …

Homeostasis of self-renewing small intestinal crypts results from neutral competition
between Lgr5 stem cells, which are small cycling cells located at crypt bottoms,. Lgr5 stem …

R-spondin proteins strongly potentiate Wnt signalling and function as stem-cell growth
factors. Despite the biological and therapeutic significance, the molecular mechanism of R …

The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven
proliferative compartments. We find that conditional deletion of both genes in the mouse gut …