The intestinal immune system in obesity and insulin resistance
Obesity and insulin resistance are associated with chronic inflammation in metabolic tissues
such as adipose tissue and the liver. Recently, growing evidence has implicated the …
such as adipose tissue and the liver. Recently, growing evidence has implicated the …
[HTML][HTML] Oral tolerance to food protein
O Pabst, AM Mowat - Mucosal immunology, 2012 - Elsevier
Oral tolerance is the state of local and systemic immune unresponsiveness that is induced
by oral administration of innocuous antigen such as food proteins. An analogous but more …
by oral administration of innocuous antigen such as food proteins. An analogous but more …
Dendritic cells: translating innate to adaptive immunity
RM Steinman, H Hemmi - From innate immunity to immunological memory, 2006 - Springer
The innate immune system provides many ways to quickly resist infection. The twobest-
studieddefenses indendritic cells (DCs) are the productionof protective cytokines—like …
studieddefenses indendritic cells (DCs) are the productionof protective cytokines—like …
Reversal of the TCR stop signal by CTLA-4
The coreceptor cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is pivotal in
regulating the threshold of signals during T cell activation, although the underlying …
regulating the threshold of signals during T cell activation, although the underlying …
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo
Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but
it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy …
it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy …
T-cell activation by dendritic cells in the lymph node: lessons from the movies
P Bousso - Nature Reviews Immunology, 2008 - nature.com
Interactions between T cells and dendritic cells (DCs) in the lymph nodes are crucial for
initiating cell-mediated adaptive immune responses. With the help of two-photon imaging …
initiating cell-mediated adaptive immune responses. With the help of two-photon imaging …
In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor
A Boissonnas, L Fetler, IS Zeelenberg… - The Journal of …, 2007 - rupress.org
Although the immune system evolved to fight infections, it may also attack and destroy solid
tumors. In most cases, tumor rejection is initiated by CD8+ cytotoxic T lymphocytes (CTLs) …
tumors. In most cases, tumor rejection is initiated by CD8+ cytotoxic T lymphocytes (CTLs) …
Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors
Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but
their impact on disease progression remains unknown. We have found in aged Apoe …
their impact on disease progression remains unknown. We have found in aged Apoe …
Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance
The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal
immune responses. RA is produced by gut-associated dendritic cells (DC) and is required …
immune responses. RA is produced by gut-associated dendritic cells (DC) and is required …
CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo
T Worbs, TR Mempel, J Bölter… - The Journal of …, 2007 - rupress.org
In contrast to lymphocyte homing, little is known about molecular cues controlling the motility
of lymphocytes within lymphoid organs. Applying intravital two-photon microscopy, we …
of lymphocytes within lymphoid organs. Applying intravital two-photon microscopy, we …