Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Background: Tacrolimus (Tac, or FK506), a calcineurin inhibitor (CNI), is the first-line
immunosuppressant which consists of the footstone as immunosuppressive regimens in …

Blood flow (BF) increases with increasing exercise intensity in skeletal, respiratory, and
cardiac muscle. In humans during maximal exercise intensities, 85% to 90% of total cardiac …

Zoo Animal and Wildlife Immobilization and Anesthesia is the definitive, comprehensive
reference for the growing fields of zoo, wildlife, and exotic animal veterinary medicine. This …

Expression of p16 INK4a and other cell cycle regulator and senescence associated genes in
aging human kidney. Background Somatic cells in vitro have a finite life expectancy before …

Epoxyeicosatrienoic acids (EETs) have antihypertensive properties and play a part in the
maintenance of renal microvascular function. A novel approach to increase EET levels is to …

Although knowledge of human renal cytochrome P450 (CYP) and UDP‐
glucuronosyltransferase (UGT) enzymes and their role in xenobiotic and endobiotic …

Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA), such as
epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, serve as second …