Early-onset cancer in the gastrointestinal tract is on the rise—evidence and implications

I Ben-Aharon, HWM van Laarhoven, E Fontana… - Cancer …, 2023 - aacrjournals.org
Epidemiologic data indicate a significant increase in the incidence of colorectal cancer in
younger populations in the past three decades. Moreover, recent evidence also …

Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: A narrative review

WJ Mei, M Mi, J Qian, N **ao, Y Yuan… - Frontiers in …, 2022 - frontiersin.org
Colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch
repair (dMMR) show molecular and clinicopathological characteristics that differ from those …

Survival outcome and prognostic factors for early-onset and late-onset metastatic colorectal cancer: a population based study from SEER database

B Ren, Y Yang, Y Lv, K Liu - Scientific Reports, 2024 - nature.com
Colorectal cancer is the third most common cancer worldwide and there has been a
concerning increase in the incidence rate of colorectal cancer among individuals under the …

Diet as a risk factor for early-onset colorectal adenoma and carcinoma: a systematic review

KL Carroll, AD Frugé, MJ Heslin, EA Lipke… - Frontiers in …, 2022 - frontiersin.org
Background Colorectal cancer in adults 50 years old and younger is increasing in incidence
worldwide. Diet may be a modifiable risk factor. The objective of this study was to examine …

Molecular genetics of early-onset colorectal cancer

O Marx, M Mankarious… - World Journal of Biological …, 2023 - pmc.ncbi.nlm.nih.gov
Early-onset colorectal cancer (EOCRC) has been rising in global prevalence and incidence
over the past several decades. Environmental influences, including generational lifestyle …

National and subnational incidence, mortality and associated factors of colorectal cancer in China: a systematic analysis and modelling study

L Xu, J Zhao, Z Li, J Sun, Y Lu, R Zhang… - Journal of Global …, 2023 - pmc.ncbi.nlm.nih.gov
Background Due to their known variation by geography and economic development, we
aimed to evaluate the incidence and mortality of colorectal cancer (CRC) in China over the …

Molecular, socioeconomic, and clinical factors affecting racial and ethnic disparities in colorectal cancer survival

M Yousef, A Yousef, S Chowdhury… - JAMA …, 2024 - jamanetwork.com
Importance Disparity in overall survival (OS) and differences in the frequency of driver gene
variants by race and ethnicity have been separately observed in patients with colorectal …

[HTML][HTML] A perspective review on diet quality, excess adiposity, and chronic psychosocial stress and implications for early-onset colorectal cancer

ML Oliveira, A Biggers, VM Oddo, B Yanez… - The Journal of …, 2024 - Elsevier
Colorectal cancer (CRC) is the third most common cancer worldwide. Although the overall
incidence of CRC has been decreasing over the past 40 y, early-onset colorectal cancer …

A multi-omics overview of colorectal cancer to address mechanisms of disease, metastasis, patient disparities and outcomes

G Yang, X Yu, DJ Weisenberger, T Lu, G Liang - Cancers, 2023 - mdpi.com
Simple Summary Human colorectal cancer (CRC) is a global health burden, most notably for
minority populations. While screening tools have helped improve disease detection and …

Who, where, when: Colorectal cancer disparities by race and ethnicity, subsite, and stage

KM Primm, AJ Malabay, T Curry, S Chang - Cancer medicine, 2023 - Wiley Online Library
Background There are well‐established disparities in colorectal cancer (CRC) outcomes
between White and Black patients; however, assessments of CRC disparities for other …