Therapeutic strategies targeting FOXO transcription factors

G Calissi, EWF Lam, W Link - Nature reviews Drug discovery, 2021 - nature.com
FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

FOXO transcription factor family in cancer and metastasis

Y Jiramongkol, EWF Lam - Cancer and Metastasis Reviews, 2020 - Springer
Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

FOXO3a in cancer drug resistance

Y Liu, Y Wang, X Li, Y Jia, J Wang, X Ao - Cancer Letters, 2022 - Elsevier
Cancer is one of the major causes of death and a significant obstacle to increasing life
expectancy worldwide. Chemotherapy remains the first-line adjuvant therapeutic option for …

The FOXO family of transcription factors: key molecular players in gastric cancer

Y Liu, X Ao, Y Jia, X Li, Y Wang, J Wang - Journal of Molecular Medicine, 2022 - Springer
Gastric cancer (GC) is the fifth most frequently diagnosed cancer worldwide and the third
leading cause of cancer-related death with an oncological origin. Despite its decline in …

Cardamonin promotes the apoptosis and chemotherapy sensitivity to gemcitabine of pancreatic cancer through modulating the FOXO3a-FOXM1 axis

H Sun, N Zhang, Y **, H Xu - Dose-Response, 2021 - journals.sagepub.com
Cardamonin (CAR), a flavone existing in the Alpinia plant, has been found to modulate
multiple biological activities, including antioxidant, anti-inflammatory, and anti-tumor effects …

Assessment of pharmacological interactions between SIRT2 inhibitor AGK2 and paclitaxel in different molecular subtypes of breast cancer cells

A Wawruszak, J Luszczki, A Czerwonka, E Okon… - Cells, 2022 - mdpi.com
Breast carcinoma (BC) is the most commonly diagnosed type of cancer in women in the
world. Although the advances in the treatment of BC patients are significant, numerous side …

ROS-induced SIRT2 upregulation contributes to cisplatin sensitivity in ovarian cancer

W Wang, J Im, S Kim, S Jang, Y Han, KM Yang, SJ Kim… - Antioxidants, 2020 - mdpi.com
Cisplatin resistance remains a significant obstacle for improving the clinical outcome of
ovarian cancer patients. Recent studies have demonstrated that cisplatin is an important …

Treatment with autophagic inhibitors enhances oligonol‑induced apoptotic effects in nasopharyngeal carcinoma cells

YT Wu, CH Lin, WC Chiu, TJ Hsieh… - Biomedical …, 2024 - spandidos-publications.com
Although the combination of chemotherapy and radiotherapy has increased the survival rate
of patients with nasopharyngeal carcinoma (NPC), certain patients do not respond well to …

TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation

Z Liu, C Li, C Yu, Z Chen, C Zhao… - Future Medicinal Chemistry, 2022 - Taylor & Francis
Background: Colorectal cancer (CRC) is a malignancy with high mortality. TSPYL2
participates in tumor suppression but its role in CRC remains unknown. Methodology & …

[HTML][HTML] HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma

X Sun, K Zhang, X Peng, P Zhou, C Qu, L Yang, L Shen - Cancer Letters, 2023 - Elsevier
Studies have shown that acetylation modification plays an important role in tumor
proliferation and metastasis. Phospholysine phosphohistidine inorganic pyrophosphate …