Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is
characterized by high recurrence and heterogeneity, yet its mechanism is not well …

RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programs. They affect diverse eukaryotic biological processes, and the correct …

Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two
species of mitochondrial (mt-) tRNAs encoded in mtDNA translate essential subunits of the …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with
impaired electron transport chain activity, NADH accumulation can be toxic. To minimize …

Autism spectrum disorder (ASD) affects~ 2% of children in the United States. The etiology of
ASD likely involves environmental factors triggering physiological abnormalities in …