Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important
mediator of gene expression patterns in tumors, although the range of responding genes is …

Angiogenesis and disruption of liver vascular architecture have been linked to progression
to cirrhosis and liver cancer (HCC) in chronic liver diseases, which contributes both to …

Liver cirrhosis is a frequent consequence of the long clinical course of all chronic liver
diseases and is characterized by tissue fibrosis and the conversion of normal liver …

Cirrhosis consists of hepatocyte nodules surrounded by a highly vascularized fibrous tissue.
We previously showed that the development of biliary cirrhosis in the rat is associated with …

The renin‐angiotensin system (RAS) is frequently activated in patients with chronic liver
diseases. Angiotensin‐II (AT‐II) has been suggested to play an important role in liver …

Background: It has been shown that expression of the potent angiogenic factor, vascular
endothelial growth factor (VEGF), and its receptors, flt-1 (VEGFR-1) and KDR/Flk-1 (VEGFR …

The term cirrhosis itself and the liver pathology it indicates, have been a source of confusion
and debate at the beginning of the 20th century, and apparently remains so at the start of the …

Liver injury causes vascular disorganization and local tissue hypoxia starting early in
disease course. In this context, hypoxia acts not only as an aggravating factor of cell damage …