Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can
provide important prognostic information in diverse solid tumor types, and may also be of …

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration
correlates with lower patient survival and resistance to therapy. Tumor-associated …

The functions of the tumor microenvironment (TME) are orchestrated by precise spatial
organization of specialized cells, yet little is known about the multicellular structures that …

In triple-negative breast cancer (TNBC), stromal restriction of CD8+ T cells associates with
poor clinical outcomes and lack of responsiveness to immune-checkpoint blockade (ICB). To …

Purpose The aim of the current study was to conduct a pooled analysis of studies that have
investigated the prognostic value of tumor-infiltrating lymphocytes (TILs) in early-stage triple …

Background Understanding the impact of the tumor immune microenvironment and
BRCA1/2-related DNA repair deficiencies on the clinical activity of immune checkpoint …

Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment.
Here, we characterize four CAF subsets in breast cancer with distinct properties and levels …

The quantity of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is a robust
prognostic factor for improved patient survival, particularly in triple-negative and HER2 …

Understanding the tumor immune microenvironment (TIME) promises to be key for optimal
cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial …