Evolving therapeutic landscape of advanced hepatocellular carcinoma
C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …
A large proportion of patients with HCC are diagnosed at advanced stages and are only …
Therapeutic targeting of “undruggable” MYC
Summary c-MYC controls global gene expression and regulates cell proliferation, cell
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …
Targeting oncogenic Myc as a strategy for cancer treatment
H Chen, H Liu, G Qing - Signal transduction and targeted therapy, 2018 - nature.com
The MYC family oncogene is deregulated in> 50% of human cancers, and this deregulation
is frequently associated with poor prognosis and unfavorable patient survival. Myc has a …
is frequently associated with poor prognosis and unfavorable patient survival. Myc has a …
Inducing and exploiting vulnerabilities for the treatment of liver cancer
Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical
dependencies,; broad-spectrum kinase inhibitors such as sorafenib provide only a modest …
dependencies,; broad-spectrum kinase inhibitors such as sorafenib provide only a modest …
Necroptosis microenvironment directs lineage commitment in liver cancer
M Seehawer, F Heinzmann, L D'artista, J Harbig… - Nature, 2018 - nature.com
Primary liver cancer represents a major health problem. It comprises hepatocellular
carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ markedly with …
carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ markedly with …
Target gene-independent functions of MYC oncoproteins
Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …
body of evidence indicates that MYC proteins are transcription factors, studying their function …
The functional diversity of Aurora kinases: a comprehensive review
E Willems, M Dedobbeleer, M Digregorio, A Lombard… - Cell division, 2018 - Springer
Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer
The transition from castration-resistant prostate adenocarcinoma (CRPC) to neuroendocrine
prostate cancer (NEPC) has emerged as an important mechanism of treatment resistance …
prostate cancer (NEPC) has emerged as an important mechanism of treatment resistance …
Clinical and biological significances of a ferroptosis-related gene signature in glioma
S Zhuo, Z Chen, Y Yang, J Zhang, J Tang… - Frontiers in …, 2020 - frontiersin.org
Ferroptosis is a form of cell death characterized by non-apoptosis induced by small
molecules in tumors. Studies have demonstrated that ferroptosis regulates the biological …
molecules in tumors. Studies have demonstrated that ferroptosis regulates the biological …
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
Abstract Treatment options for COVID‐19, caused by SARS‐CoV‐2, remain limited.
Understanding viral pathogenesis at the molecular level is critical to develop effective …
Understanding viral pathogenesis at the molecular level is critical to develop effective …