Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …

Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …

The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the …

The unabated progress in next-generation sequencing technologies is fostering a wave of
new genomics, epigenomics, transcriptomics and proteomics technologies. These …

Tracking the progeny of single cells is necessary for building lineage trees that recapitulate
processes such as embryonic development and stem cell differentiation. In classical lineage …

The ovary, the female gonad, serves as the source for the germ cells as well as the major
supplier of steroid sex hormones. During embryonic development, the primordial germ cells …

Germline mutations are the source of evolution and contribute substantially to many health-
related processes. Here we use whole-genome deep sequencing data from 693 parents …

Resolving lineage relationships between cells in an organism is a fundamental interest of
developmental biology. Furthermore, investigating lineage can drive understanding of …

Because germline mutations are the source of all evolutionary adaptations and heritable
diseases, characterizing their properties and the rate at which they arise across individuals …