Immunotherapy has emerged as a key pillar of cancer treatment. To build upon the recent
successes of immunotherapy, intense research efforts are aimed at a molecular …

Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …

Metabolic reprogramming is one of the most important hallmarks of malignant tumors.
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …

Chemo-immunotherapy holds the advantage of specific antitumor effects by activating T cell
immune response. However, the efficiency of chemo-immunotherapy is restricted to the …

Exosomal release pathway and autophagy together maintain homeostasis and survival of
cells under stressful conditions. Autophagy is a catabolic process through which cell entities …

Abstract MHC class II (MHCII) expression is usually restricted to APC but can be expressed
by cancer cells. We examined the effect of cancer cell–specific MHCII (csMHCII) expression …

Tumor‐draining lymph nodes (TDLNs) are the first sites where tumor components reach and
dendritic cells (DCs) present tumor‐associated antigens to T cells. DCs rely on autophagy to …

Mycobacterium tuberculosis (Mtb) is responsible for approximately 1.5 million deaths each
year. Though 10% of patients develop tuberculosis (TB) after infection, 90% of these …

Dendritic cells (DCs), as the most powerful antigen presenting cells, play a critical role in
regulating immune response and anti-tumor process. However, the immunosuppressive …

Widespread coronavirus disease (COVID)-19 is causing pneumonia, respiratory and
multiorgan failure in susceptible individuals. Dysregulated immune response marks severe …