Emerging evidence for adapting radiotherapy to immunotherapy

L Galluzzi, MJ Aryankalayil, CN Coleman… - Nature reviews Clinical …, 2023 - nature.com
Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …

Killing two birds with one stone: Abscopal effect mechanism and its application prospect in radiotherapy

B Yu, Y Gao, J Li, F Gao, J Zhang, L Li, X Feng… - Critical Reviews in …, 2024 - Elsevier
Abscopal effects are characterized by the emergence of neoplasms in regions unrelated to
the primary radiation therapy site, displaying a gradual attenuation or regression throughout …

Synergistic local combination of radiation and anti-programmed death ligand 1 immunotherapy using radiation-responsive splintery metallic nanocarriers

B Choi, H Choi, B Yu, DH Kim - ACS nano, 2020 - ACS Publications
Radiation therapy (RT)-mediated tumor immunogenicity offers an opportunity for synergistic
combination RT and immunotherapy. One of the challenges in the clinic is to attain the …

[HTML][HTML] A patient-level data meta-analysis of the abscopal effect

SJ Hatten Jr, EJ Lehrer, J Liao, MS Congzhou… - Advances in Radiation …, 2022 - Elsevier
Purpose The abscopal effect is defined when a form of local therapy causes tumor
regression of both the target lesion and any untreated tumors. Herein cases of the abscopal …

Impact of proton therapy on antitumor immune response

C Mirjolet, A Nicol, E Limagne, C Mura, C Richard… - Scientific Reports, 2021 - nature.com
Radiotherapy delivered using photons induces an immune response that leads to
modulation of the tumor microenvironment. Clinical studies are ongoing to evaluate immune …

Gastric cancer with brain metastasis: from molecular characteristics and treatment

Y Zhu, M Zhou, C Li, W Kong, Y Hu - Frontiers in Oncology, 2024 - frontiersin.org
Gastric cancer is one of the cancers with increasing incidence and ranks fourth globally
among the most frequent causes of cancer-related mortality. Early gastric cancer is often …

Immunostimulatory effects of radiotherapy for local and systemic control of melanoma: A review

J Takahashi, S Nagasawa - International journal of molecular sciences, 2020 - mdpi.com
Recently, modern therapies involving immune checkpoint inhibitors, cytokines, and oncolytic
virus have been developed. Because of the limited treatment effect of modern therapy alone …

Charged particle and conventional radiotherapy: current implications as partner for immunotherapy

D Marcus, RIY Lieverse, C Klein, A Abdollahi… - Cancers, 2021 - mdpi.com
Simple Summary Immunotherapy provides the unprecedented opportunity to prolong the
survival of cancer patients and even cure patients with previously untreatable malignancies …

[HTML][HTML] Phase II trial of combined durvalumab plus tremelimumab with proton therapy for recurrent or metastatic head and neck squamous cell carcinoma

H Kim, S Park, HA Jung, SH Lee… - … : Official Journal of …, 2023 - synapse.koreamed.org
Purpose This phase II study investigated whether durvalumab/tremelimumab with proton
therapy improves the objective response rate (ORR), overall survival (OS), and progression …

Multi‐institutional analysis of stereotactic body radiotherapy for sarcoma pulmonary metastases: high rates of local control with favorable toxicity

BC Baumann, KDA Bernstein… - Journal of surgical …, 2020 - Wiley Online Library
Abstract Background/Objectives Oligometastatic sarcoma pulmonary metastases (PM's) are
traditionally treated with resection and/or chemotherapy. We hypothesize that stereotactic …