β2-Agonists are effective bronchodilators due primarily to their ability to relax airway smooth
muscle (ASM). They exert their effects via their binding to the active site of β2-adrenoceptors …

A concise review covering updated presence and role of 2-phenethylamines in medicinal
chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are …

Background Whether the combination of a once-daily inhaled corticosteroid with a once-
daily longacting β 2 agonist is more protective than a once-daily longacting β 2 agonist …

Background: β2‐adrenoreceptors have recently been identified as regulators of the α‐
synuclein gene, which is implicated in the pathogenesis of Parkinson's disease. Objective …

Asthma is a heterogeneous inflammatory disease of the airways that is associated with
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …

Respiratory inflammation is caused by an air‐mediated disease induced by polluted air,
smoke, bacteria, and viruses. The COVID‐19 pandemic is also a kind of respiratory disease …

Abstract Treatment of obesity with repurposed or novel drugs is an expanding research field.
One approach is to target beta2‐adrenergic receptors because they regulate the metabolism …

Highlights•Inhaled medicines are cornerstones in the treatment of asthma/COPD
today.•Significant unmet medical need remains in the treatment of respiratory diseases.•The …

Research using animal models of asthma is currently dominated by mouse models. This has
been driven by the comprehensive knowledge on inflammatory and immune reactions in …

Highlights•Dual bronchodilator therapy has clinical benefits in COPD.•Combining a LABA
with a LAMA synergistically relaxes medium and small airways.•In some approved …