Tumor metastasis: moving new biological insights into the clinic
As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our
effort to fight cancer as a life-threatening disease. The explosive growth of metastasis …
effort to fight cancer as a life-threatening disease. The explosive growth of metastasis …
Mechanisms of metastasis
Metastatic disease is the culmination of cancer and its most common life-threatening
manifestation. The highly complex process by which cancer cells disseminate to and …
manifestation. The highly complex process by which cancer cells disseminate to and …
Genetic insights into the morass of metastatic heterogeneity
Tumour heterogeneity poses a substantial problem for the clinical management of cancer.
Somatic evolution of the cancer genome results in genetically distinct subclones in the …
Somatic evolution of the cancer genome results in genetically distinct subclones in the …
Soft sweeps are the dominant mode of adaptation in the human genome
The degree to which adaptation in recent human evolution shapes genetic variation remains
controversial. This is in part due to the limited evidence in humans for classic “hard selective …
controversial. This is in part due to the limited evidence in humans for classic “hard selective …
Platelets promote metastasis via binding tumor CD97 leading to bidirectional signaling that coordinates transendothelial migration
Y Ward, R Lake, F Faraji, J Sperger, P Martin, C Gilliard… - Cell reports, 2018 - cell.com
Tumor cells initiate platelet activation leading to the secretion of bioactive molecules, which
promote metastasis. Platelet receptors on tumors have not been well-characterized …
promote metastasis. Platelet receptors on tumors have not been well-characterized …
Epithelial-mesenchymal transition leads to NK cell–mediated metastasis-specific immunosurveillance in lung cancer
During epithelial-mesenchymal transition (EMT) epithelial cancer cells transdifferentiate into
highly motile, invasive, mesenchymal-like cells, giving rise to disseminating tumor cells. Few …
highly motile, invasive, mesenchymal-like cells, giving rise to disseminating tumor cells. Few …
Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge
Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …
treatment over the past several decades have significantly improved the outlook for this …
Melanoma metastasis: new concepts and evolving paradigms
WE Damsky, N Theodosakis, M Bosenberg - Oncogene, 2014 - nature.com
Melanoma progression is typically depicted as a linear and stepwise process in which
metastasis occurs relatively late in disease progression. Significant evidence suggests that …
metastasis occurs relatively late in disease progression. Significant evidence suggests that …
[HTML][HTML] CADM1 inhibits ovarian cancer cell proliferation and migration by potentially regulating the PI3K/Akt/mTOR pathway
X Si, F Xu, F Xu, M Wei, Y Ge, S Chenge - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Previous studies have shown that cell adhesion molecule 1 (CADM1), an immunoglobulin
superfamily member, is frequently inactivated but functions as a tumor suppressor in many …
superfamily member, is frequently inactivated but functions as a tumor suppressor in many …
Immunological consequences of epithelial–mesenchymal transition in tumor progression
PJ Chockley, VG Keshamouni - The Journal of Immunology, 2016 - journals.aai.org
Microenvironments that tumor cells encounter are different during the stages of cancer
progression—primary tumor, metastasis, and at the metastatic site. This suggests potential …
progression—primary tumor, metastasis, and at the metastatic site. This suggests potential …