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Top-down proteomics
Proteoforms, which arise from post-translational modifications, genetic polymorphisms and
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …
Top-down proteomics and the challenges of true proteoform characterization
Top-down proteomics (TDP) aims to identify and profile intact protein forms (proteoforms)
extracted from biological samples. True proteoform characterization requires that both the …
extracted from biological samples. True proteoform characterization requires that both the …
Defining proteoform-specific interactions for drug targeting in a native cell signalling environment
Understanding the dynamics of membrane protein–ligand interactions within a native lipid
bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however …
bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however …
Mass spectrometry-intensive top-down proteomics: an update on technology advancements and biomedical applications
Proteoforms are all forms of protein molecules from the same gene because of variations at
the DNA, RNA, and protein levels, eg, alternative splicing and post-translational …
the DNA, RNA, and protein levels, eg, alternative splicing and post-translational …
Recent progress in quantitative phosphoproteomics
K Zittlau, P Nashier, C Cavarischia-Rega… - Expert Review of …, 2023 - Taylor & Francis
Introduction Protein phosphorylation is a critical post-translational modification involved in
the regulation of numerous cellular processes from signal transduction to modulation of …
the regulation of numerous cellular processes from signal transduction to modulation of …
Native Top-Down Mass Spectrometry for Characterizing Sarcomeric Proteins Directly from Cardiac Tissue Lysate
Native top-down mass spectrometry (nTDMS) has emerged as a powerful structural biology
tool that can localize post-translational modifications (PTMs), explore ligand-binding …
tool that can localize post-translational modifications (PTMs), explore ligand-binding …
The 2023 report on the Proteome from the HUPO Human Proteome Project
Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human
Proteome Organization (HUPO), has pursued two goals:(1) to credibly identify the protein …
Proteome Organization (HUPO), has pursued two goals:(1) to credibly identify the protein …
Post‐translational modifications of proteins in cardiovascular diseases examined by proteomic approaches
M Stastna - The FEBS Journal, 2025 - Wiley Online Library
Over 400 different types of post‐translational modifications (PTMs) have been reported and
over 200 various types of PTMs have been discovered using mass spectrometry (MS) …
over 200 various types of PTMs have been discovered using mass spectrometry (MS) …
Post‐translational modifications of vertebrate striated muscle myosin heavy chains
PN Morales, AN Coons, AJ Koopman, S Patel… - …, 2024 - Wiley Online Library
Post‐translational modifications (PTMs) play a crucial role in regulating the function of many
sarcomeric proteins, including myosin. Myosins comprise a family of motor proteins that play …
sarcomeric proteins, including myosin. Myosins comprise a family of motor proteins that play …
Multi‐omic analyses and network biology in cardiovascular disease
Heart disease remains a leading cause of death in North America and worldwide. Despite
advances in therapies, the chronic nature of cardiovascular diseases ultimately results in …
advances in therapies, the chronic nature of cardiovascular diseases ultimately results in …