This tutorial presents the most common ion activation techniques employed in tandem mass
spectrometry. In‐source fragmentation and metastable ion decompositions, as well as the …

Multidimensional mass spectrometry interfaces a suitable ionization technique and mass
analysis (MS) with fragmentation by tandem mass spectrometry (MS2) and an orthogonal …

Mass spectrometry-based proteomics has become the tool of choice for identifying and
quantifying the proteome of an organism. Though recent years have seen a tremendous …

Understanding the molecular composition and fundamental chemical transformations of
organic aerosols (OA) during their formation and aging is both a major challenge and the …

Top-down mass spectrometry is an emerging approach for the analysis of intact proteins.
The term was coined as a contrast with the better-established, bottom-up strategy for …

Of the estimated 5 million barrels of crude oil released into the Gulf of Mexico from the
Deepwater Horizon oil spill, a fraction washed ashore onto sandy beaches from Louisiana to …

Although the advent of large-scale genomic sequencing has greatly simplified the task of
determining the primary structures of peptides and proteins, the genomic sequences of …

The advent of soft ionization techniques, notably electrospray and laser desorption
ionization methods, has enabled the extension of mass spectrometric methods to large …

Top-down electron capture dissociation (ECD) Fourier transform ion cyclotron resonance
(FTICR) mass spectrometry was performed for structural analysis of an intact monoclonal …

Key to native ion mobility/mass spectrometry is to prevent the structural denaturation of
biological molecules in the gas phase. Here, we systematically assess structural changes …