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Inhibitors of bacterial immune systems: discovery, mechanisms and applications
To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
[HTML][HTML] How do interactions between mobile genetic elements affect horizontal gene transfer?
Highlights•Collaboration and conflict between MGEs can promote and inhibit HGT•Many
genome defences are MGE-encoded, serving MGE interests and changing frequently•The …
genome defences are MGE-encoded, serving MGE interests and changing frequently•The …
PADLOC: a web server for the identification of antiviral defence systems in microbial genomes
Most bacteria and archaea possess multiple antiviral defence systems that protect against
infection by phages, archaeal viruses and mobile genetic elements. Our understanding of …
infection by phages, archaeal viruses and mobile genetic elements. Our understanding of …
Going viral: The role of mobile genetic elements in bacterial immunity
Bacteriophages and other mobile genetic elements (MGEs) pose a significant threat to
bacteria, subjecting them to constant attacks. In response, bacteria have evolved a …
bacteria, subjecting them to constant attacks. In response, bacteria have evolved a …
Synergy and regulation of antiphage systems: toward the existence of a bacterial immune system?
Highlights•Different antiphage systems are encoded in one bacterial genome.•Bacterial
antiphage systems can function in synergy through different strategies.•Antiphage systems …
antiphage systems can function in synergy through different strategies.•Antiphage systems …
Accumulation of defense systems in phage-resistant strains of Pseudomonas aeruginosa
Prokaryotes encode multiple distinct anti-phage defense systems in their genomes.
However, the impact of carrying a multitude of defense systems on phage resistance …
However, the impact of carrying a multitude of defense systems on phage resistance …
[HTML][HTML] Multi-layered genome defences in bacteria
Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic
elements, including restriction-modification systems and CRISPR–Cas. In recent years …
elements, including restriction-modification systems and CRISPR–Cas. In recent years …
Recent advances in phage defense systems and potential overcoming strategies
Bacteriophages are effective in the prevention and control of bacteria, and many phage
products have been permitted and applied in the field. Because bacteriophages are …
products have been permitted and applied in the field. Because bacteriophages are …
A host of armor: Prokaryotic immune strategies against mobile genetic elements
Prokaryotic adaptation is strongly influenced by the horizontal acquisition of beneficial traits
via mobile genetic elements (MGEs), such as viruses/bacteriophages and plasmids …
via mobile genetic elements (MGEs), such as viruses/bacteriophages and plasmids …
Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system
H Cheng, H Deng, D Ma, M Gao, Z Zhou, H Li, S Liu… - Heliyon, 2024 - cell.com
CRISPR-Cas, the adaptive immune system exclusive to prokaryotes, confers resistance
against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited …
against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited …