LRRK2 pathways leading to neurodegeneration
MR Cookson - Current neurology and neuroscience reports, 2015 - Springer
Mutations in LRRK2 are associated with inherited Parkinson's disease (PD) in a large
number of families, and the genetic locus containing the LRRK2 gene contains a risk factor …
number of families, and the genetic locus containing the LRRK2 gene contains a risk factor …
LRRK2: cause, risk, and mechanism
In 2004 it was first shown that mutations in LRRK2 can cause Parkinson's disease. This
initial discovery was quickly followed by the observation that a single particular mutation is a …
initial discovery was quickly followed by the observation that a single particular mutation is a …
Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
J Schapansky, JD Nardozzi, F Felizia… - Human molecular …, 2014 - academic.oup.com
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial
and idiopathic Parkinson's disease. However, the mechanisms for activating its …
and idiopathic Parkinson's disease. However, the mechanisms for activating its …
Identification of the rate‐determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study
Clearance of atorvastatin occurs through hepatic uptake by organic anion transporting
polypeptides (OATPs) and subsequent metabolism by cytochrome P450 (CYP) 3A4. To …
polypeptides (OATPs) and subsequent metabolism by cytochrome P450 (CYP) 3A4. To …
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
Mutations in the LRRK2 gene cause autosomal dominant Parkinson's disease. LRRK2
encodes a multi-domain protein containing a Ras-of-complex (Roc) GTPase domain, a C …
encodes a multi-domain protein containing a Ras-of-complex (Roc) GTPase domain, a C …
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation
Autosomal-dominant missense mutations in LRRK2 (leucine-rich repeat kinase 2) are a
common genetic cause of PD (Parkinson's disease). LRRK2 is a multidomain protein with …
common genetic cause of PD (Parkinson's disease). LRRK2 is a multidomain protein with …
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
Mutations in Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and
sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple …
sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple …
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers
L Civiero, R Vancraenenbroeck, E Belluzzi, A Beilina… - 2012 - journals.plos.org
Leucine-rich repeat kinase 1 and 2 (LRRK1 and LRRK2) are large multidomain proteins
containing kinase, GTPase and multiple protein-protein interaction domains, but only …
containing kinase, GTPase and multiple protein-protein interaction domains, but only …
LRRK2 kinase inhibition as a therapeutic strategy for Parkinson's disease, where do we stand?
One of the most promising therapeutic targets for potential diseasemodifying treatment of
Parkinson's disease (PD) is leucine-rich repeat kinase 2 (LRRK2). Specifically, targeting …
Parkinson's disease (PD) is leucine-rich repeat kinase 2 (LRRK2). Specifically, targeting …
A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover
E Deyaert, L Wauters, G Guaitoli… - Nature …, 2017 - nature.com
Mutations in LRRK2 are a common cause of genetic Parkinson's disease (PD). LRRK2 is a
multi-domain Roco protein, harbouring kinase and GTPase activity. In analogy with a …
multi-domain Roco protein, harbouring kinase and GTPase activity. In analogy with a …