A field guide to foldamers
The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …
DNA analogues: from supramolecular principles to biological properties
Mainly driven by the needs of antisense research, a large number of oligonucleotide
analogues have been prepared and evaluated over the last 15 years. Besides minor …
analogues have been prepared and evaluated over the last 15 years. Besides minor …
Development of nucleic acid medicines based on chemical technology
Y Kawamoto, Y Wu, Y Takahashi, Y Takakura - Advanced Drug Delivery …, 2023 - Elsevier
Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …
includes the modulation of genes and their binding proteins related to diseases, allowing us …
α-l-ribo-Configured Locked Nucleic Acid (α-L-LNA): Synthesis and Properties
MD Sørensen, L Kværnø, T Bryld… - Journal of the …, 2002 - ACS Publications
The syntheses of monomeric nucleosides and 3 '-O-phosphoramidite building blocks en
route to α-l-ribo-configured locked nucleic acids (α-L-LNA), composed entirely of α-L-LNA …
route to α-l-ribo-configured locked nucleic acids (α-L-LNA), composed entirely of α-L-LNA …
Oligonucleotide analogues
US8153365B2 - Oligonucleotide analogues - Google Patents US8153365B2 -
Oligonucleotide analogues - Google Patents Oligonucleotide analogues Download PDF …
Oligonucleotide analogues - Google Patents Oligonucleotide analogues Download PDF …
The eight stereoisomers of LNA (locked nucleic acid): a remarkable family of strong RNA binding molecules
VK Rajwanshi, AE Håkansson… - Angewandte …, 2000 - Wiley Online Library
1724 WILEY-VCH Verlag GmbH, D-69451 Weinheim, 2000 0044-8249/00/11209-1724
$17.50+. 50/0 Angew. Chem. 2000, 112, Nr. 9 towards both complementary DNA (ΔTm 3.08 …
$17.50+. 50/0 Angew. Chem. 2000, 112, Nr. 9 towards both complementary DNA (ΔTm 3.08 …
LNA (locked nucleic acid)
Abstract LNA (Locked Nucleic Acid) forms duplexes with complementary DNA, RNA or LNA
with unprecedented thermal affinities. CD spectra show that duplexes involving fully …
with unprecedented thermal affinities. CD spectra show that duplexes involving fully …
C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level
M Jurk, B Schulte, A Kritzler, B Noll, E Uhlmann… - Immunobiology, 2004 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing unmethylated deoxycytosine–
deoxyguanosine (CpG) motifs are very potent inducers of the innate immune system …
deoxyguanosine (CpG) motifs are very potent inducers of the innate immune system …
Bicyclic nucleosides and conformational restriction of oligonucleotides
Bicyclic nucleosides and conformational restriction of oligonucleotides - Journal of the Chemical
Society, Perkin Transactions 1 (RSC Publishing) DOI:10.1039/B000114G Royal Society of …
Society, Perkin Transactions 1 (RSC Publishing) DOI:10.1039/B000114G Royal Society of …
Chemistry of locked nucleic acids (LNA): Design, synthesis, and bio-physical properties
Preparation of LNA nucleosides requires a number of synthetic steps but very efficient
procedures have been developed, as have protocols for synthesis of LNA oligonucleotides …
procedures have been developed, as have protocols for synthesis of LNA oligonucleotides …