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Cancer cachexia: molecular mechanisms and treatment strategies
Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …
The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment
D Aguilar-Cazares, R Chavez-Dominguez… - Frontiers in …, 2022 - frontiersin.org
The tumor microenvironment is a dynamic, complex, and redundant network of interactions
between tumor, immune, and stromal cells. In this intricate environment, cells communicate …
between tumor, immune, and stromal cells. In this intricate environment, cells communicate …
Ketogenic diets in pancreatic cancer and associated cachexia: cellular mechanisms and clinical perspectives
NE Cortez, GG Mackenzie - Nutrients, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and extremely therapy-resistant
cancer. It is estimated that up to 80% of PDAC patients present with cachexia, a multifactorial …
cancer. It is estimated that up to 80% of PDAC patients present with cachexia, a multifactorial …
Blood biomarkers as potential malnutrition screening alternatives among adult patients with cancer on treatment in oncology unit of jimma tertiary hospital: A cross …
A Enkobahry, T Sime, K Kene, T Mateos, S Dilnesa… - BMC nutrition, 2023 - Springer
Background Cancer is becoming the most common global public health concern. Early
malnutrition detection and treatment in patients with cancer is an important aspect of cancer …
malnutrition detection and treatment in patients with cancer is an important aspect of cancer …
Astaxanthin Supplementation Assists Sorafenib in Slowing Skeletal Muscle Atrophy in H22 Tumor‐Bearing Mice via Reversing Abnormal Glucose Metabolism
P Ren, X Yu, Q Tang, Y Huan, J Xu… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Cachexia, which is often marked by skeletal muscular atrophy, is one of the leading
causes of death in cancer patients. Astaxanthin, a carotenoid obtained from marine …
causes of death in cancer patients. Astaxanthin, a carotenoid obtained from marine …
Targeting cancer cachexia: Molecular mechanisms and clinical study
Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle
wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer …
wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer …
Placenta: an old organ with new functions
S Khorami-Sarvestani, N Vanaki, S Shojaeian… - Frontiers in …, 2024 - frontiersin.org
The transition from oviparity to viviparity and the establishment of feto-maternal
communications introduced the placenta as the major anatomical site to provide nutrients …
communications introduced the placenta as the major anatomical site to provide nutrients …
Current advancements in pharmacotherapy for cancer cachexia
GWP da Fonseca, R Sato… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Cancer cachexia is a multifactorial metabolic syndrome associated with a
pathophysiology intertwined with increased inflammatory response, anorexia, metabolic …
pathophysiology intertwined with increased inflammatory response, anorexia, metabolic …
2-deoxy-D-glucose alleviates cancer cachexia-induced muscle wasting by enhancing ketone metabolism and inhibiting the cori cycle
Cachexia is characterized by progressive weight loss accompanied by the loss of specific
skeletal muscle and adipose tissue. Increased lactate production, either due to the Warburg …
skeletal muscle and adipose tissue. Increased lactate production, either due to the Warburg …
CCL2 signaling promotes skeletal muscle wasting in non-tumor and breast tumor models
N Alissa, WB Fang, M Medrano… - Disease Models & …, 2024 - journals.biologists.com
Despite advancements in treatment, approximately 25% of patients with breast cancer
experience long-term skeletal muscle wasting (SMW), which limits mobility, reduces drug …
experience long-term skeletal muscle wasting (SMW), which limits mobility, reduces drug …