Cancer cachexia: molecular mechanisms and treatment strategies

T Setiawan, IN Sari, YT Wijaya, NM Julianto… - Journal of Hematology & …, 2023 - Springer
Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment

D Aguilar-Cazares, R Chavez-Dominguez… - Frontiers in …, 2022 - frontiersin.org
The tumor microenvironment is a dynamic, complex, and redundant network of interactions
between tumor, immune, and stromal cells. In this intricate environment, cells communicate …

Ketogenic diets in pancreatic cancer and associated cachexia: cellular mechanisms and clinical perspectives

NE Cortez, GG Mackenzie - Nutrients, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and extremely therapy-resistant
cancer. It is estimated that up to 80% of PDAC patients present with cachexia, a multifactorial …

Blood biomarkers as potential malnutrition screening alternatives among adult patients with cancer on treatment in oncology unit of jimma tertiary hospital: A cross …

A Enkobahry, T Sime, K Kene, T Mateos, S Dilnesa… - BMC nutrition, 2023 - Springer
Background Cancer is becoming the most common global public health concern. Early
malnutrition detection and treatment in patients with cancer is an important aspect of cancer …

Astaxanthin Supplementation Assists Sorafenib in Slowing Skeletal Muscle Atrophy in H22 Tumor‐Bearing Mice via Reversing Abnormal Glucose Metabolism

P Ren, X Yu, Q Tang, Y Huan, J Xu… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Cachexia, which is often marked by skeletal muscular atrophy, is one of the leading
causes of death in cancer patients. Astaxanthin, a carotenoid obtained from marine …

Targeting cancer cachexia: Molecular mechanisms and clinical study

YF Wang, ZY An, DH Lin, WL ** - MedComm, 2022 - Wiley Online Library
Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle
wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer …

Placenta: an old organ with new functions

S Khorami-Sarvestani, N Vanaki, S Shojaeian… - Frontiers in …, 2024 - frontiersin.org
The transition from oviparity to viviparity and the establishment of feto-maternal
communications introduced the placenta as the major anatomical site to provide nutrients …

Current advancements in pharmacotherapy for cancer cachexia

GWP da Fonseca, R Sato… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Cancer cachexia is a multifactorial metabolic syndrome associated with a
pathophysiology intertwined with increased inflammatory response, anorexia, metabolic …

2-deoxy-D-glucose alleviates cancer cachexia-induced muscle wasting by enhancing ketone metabolism and inhibiting the cori cycle

L Wei, R Wang, J Wazir, K Lin, S Song, L Li, W Pu… - Cells, 2022 - mdpi.com
Cachexia is characterized by progressive weight loss accompanied by the loss of specific
skeletal muscle and adipose tissue. Increased lactate production, either due to the Warburg …

CCL2 signaling promotes skeletal muscle wasting in non-tumor and breast tumor models

N Alissa, WB Fang, M Medrano… - Disease Models & …, 2024 - journals.biologists.com
Despite advancements in treatment, approximately 25% of patients with breast cancer
experience long-term skeletal muscle wasting (SMW), which limits mobility, reduces drug …