Importance Malignant primary brain tumors cause more than 15 000 deaths per year in the
United States. The annual incidence of primary malignant brain tumors is approximately 7 …

A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …

Background Isocitrate dehydrogenase (IDH)–mutant grade 2 gliomas are malignant brain
tumors that cause considerable disability and premature death. Vorasidenib, an oral brain …

The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …

Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant
primary brain tumors diagnosed in patients younger than 50, constituting an important cause …

Importance Previous histologic classifications of brain tumors have been limited by
discrepancies in diagnoses reported by neuropathologists and variability in outcomes and …

Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Purpose To provide guidance to clinicians regarding therapy for diffuse astrocytic and
oligodendroglial tumors in adults. Methods ASCO and the Society for Neuro-Oncology …

Glioma represents a dominant primary intracranial malignancy in the central nervous
system. Artificial intelligence that mainly includes machine learning, and deep learning …

Clinical trials frequently include multiple end points that mature at different times. The initial
report, typically based on the basis of the primary end point, may be published when key …