Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

M Masoodi, A Gastaldelli, T Hyötyläinen… - Nature reviews …, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide and is often associated with aspects of metabolic syndrome. Despite its …

Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade

H Tilg, TE Adolph, AR Moschen - Hepatology, 2021 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is an epidemic liver disease, affecting
approximately one quarter of the entire population in the world.(1) This disease …

[HTML][HTML] Diabetes mellitus—Progress and opportunities in the evolving epidemic

ED Abel, AL Gloyn, C Evans-Molina, JJ Joseph… - Cell, 2024 - cell.com
Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Oxidative stress in non-alcoholic fatty liver disease. An updated mini review

AP Delli Bovi, F Marciano, C Mandato, MA Siano… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it remains still orphan of an adequate therapeutic …

Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: a bedside to bench investigation

CW Kim, C Addy, J Kusunoki, NN Anderson, S Deja… - Cell metabolism, 2017 - cell.com
Inhibiting lipogenesis prevents hepatic steatosis in rodents with insulin resistance. To
determine if reducing lipogenesis functions similarly in humans, we developed MK-4074, a …

[HTML][HTML] Oxidative stress in non-alcoholic fatty liver disease. An updated mini review

APD Bovi, F Marciano, C Mandato, MA Siano… - Frontiers in …, 2021 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it remains still orphan of an adequate therapeutic …

Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio Metabolism Study

A Gastaldelli, M Gaggini, RA DeFronzo - Diabetes, 2017 - Am Diabetes Assoc
In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome

P Dietrich, C Hellerbrand - Best practice & research Clinical …, 2014 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is now recognized as the most common cause of
chronic liver disease worldwide. Its prevalence has increased to more than 30% of adults in …

Nonalcoholic fatty liver disease pandemic fuels the upsurge in cardiovascular diseases

J Cai, XJ Zhang, YX Ji, P Zhang, ZG She… - Circulation research, 2020 - Am Heart Assoc
Cardiovascular diseases (CVDs) remain a leading cause of death worldwide. Among the
major risk factors for CVD, obesity and diabetes mellitus have received considerable …