[HTML][HTML] Advantages and limitations of bacteriophages for the treatment of bacterial infections

N Principi, E Silvestri, S Esposito - Frontiers in pharmacology, 2019 - frontiersin.org
Bacteriophages (BPs) are viruses that can infect and kill bacteria without any negative effect
on human or animal cells. For this reason, it is supposed that they can be used, alone or in …

[HTML][HTML] Interactions between bacteriophage, bacteria, and the mammalian immune system

JD Van Belleghem, K Dąbrowska, M Vaneechoutte… - Viruses, 2018 - mdpi.com
The human body is host to large numbers of bacteriophages (phages)–a diverse group of
bacterial viruses that infect bacteria. Phage were previously regarded as bystanders that …

Expansion of bacteriophages is linked to aggravated intestinal inflammation and colitis

L Gogokhia, K Buhrke, R Bell, B Hoffman, DG Brown… - Cell host & …, 2019 - cell.com
Bacteriophages are the most abundant members of the microbiota and have the potential to
shape gut bacterial communities. Changes to bacteriophage composition are associated …

Immunogenicity of bacteriophages

K Champagne-Jorgensen, T Luong, T Darby… - Trends in …, 2023 - cell.com
Hundreds of trillions of diverse bacteriophages (phages) peacefully thrive within and on the
human body. However, whether and how phages influence their mammalian hosts is poorly …

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

K Dąbrowska - Medicinal research reviews, 2019 - Wiley Online Library
Bacteriophages are not forgotten viruses anymore: scientists and practitioners seek to
understand phage pharmacokinetics in animals and humans, investigating bacteriophages …

Bacteriophages and the immune system

M Popescu, JD Van Belleghem… - Annual review of …, 2021 - annualreviews.org
Bacteriophages—viruses that infect bacteria—are abundant within our bodies, but their
significance to human health is only beginning to be explored. Here, we synthesize what is …

Bacteriophages and their potential for treatment of gastrointestinal diseases

Y Duan, R Young, B Schnabl - Nature reviews Gastroenterology & …, 2022 - nature.com
Although bacteriophages have been overshadowed as therapeutic agents by antibiotics for
decades, the emergence of multidrug-resistant bacteria and a better understanding of the …

Bacteriophage defends murine gut from Escherichia coli invasion via mucosal adherence

J Wu, K Fu, C Hou, Y Wang, C Ji, F Xue, J Ren… - Nature …, 2024 - nature.com
Bacteriophage are sophisticated cellular parasites that can not only parasitize bacteria but
are increasingly recognized for their direct interactions with mammalian hosts. Phage …

Phages and their potential to modulate the microbiome and immunity

S Federici, SP Nobs, E Elinav - Cellular & molecular immunology, 2021 - nature.com
Bacteriophages (hence termed phages) are viruses that target bacteria and have long been
considered as potential future treatments against antibiotic-resistant bacterial infection …

Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages

JD Van Belleghem, F Clement, M Merabishvili… - Scientific reports, 2017 - nature.com
The ability of bacteriophages to kill bacteria is well known, as is their potential use as
alternatives to antibiotics. As such, bacteriophages reach high doses locally through …