The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

The pathobiology of human fungal infections

GD Brown, ER Ballou, S Bates, EM Bignell… - Nature Reviews …, 2024 - nature.com
Human fungal infections are a historically neglected area of disease research, yet they
cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of …

Candida auris Outbreaks: Current Status and Future Perspectives

S De Gaetano, A Midiri, G Mancuso, MG Avola… - Microorganisms, 2024 - mdpi.com
Candida auris has been identified by the World Health Organization (WHO) as a critical
priority pathogen on its latest list of fungi. C. auris infections are reported in the bloodstream …

Mechanisms of pathogenicity for the emerging fungus Candida auris

MV Horton, AM Holt, JE Nett - PLoS Pathogens, 2023 - journals.plos.org
Candida auris recently emerged as an urgent public health threat, causing outbreaks of
invasive infections in healthcare settings throughout the world. This fungal pathogen persists …

Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities

LJ Jia, K González, T Orasch, F Schmidt… - Nature …, 2024 - nature.com
An important host defence mechanism against pathogens is intracellular killing, which is
achieved through phagocytosis, a cellular process for engulfing and neutralizing …

Pathogenesis, Prophylaxis, and Treatment of Candida auris

M Preda, RD Chivu, LM Ditu, O Popescu… - Biomedicines, 2024 - mdpi.com
Candida auris poses a serious threat to infection control and patient care since it can
produce invasive infections that have a high fatality rate, has been linked to outbreaks in …

Candida auris—macrophage cellular interactions and transcriptional response

P Miramón, AW Pountain, MC Lorenz - Infection and Immunity, 2023 - journals.asm.org
The pathogenic yeast Candida auris represents a global threat of the utmost clinical
relevance. This emerging fungal species is remarkable in its resistance to commonly used …

Fungal primary and opportunistic pathogens: an ecological perspective

S de Hoog, C Tang, X Zhou, B Jacomel… - FEMS Microbiology …, 2024 - academic.oup.com
Fungal primary pathogenicity on vertebrates is here described as a deliberate strategy
where the host plays a role in increasing the species' fitness. Opportunism is defined as the …

Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities

R Silva-Gomes, I Caldeira, R Fernandes… - Journal of Leukocyte …, 2024 - academic.oup.com
Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …

Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems

H Weerasinghe, H Stölting, AJ Rose… - … and Molecular Biology …, 2024 - journals.asm.org
The ability to overcome metabolic stress is a major determinant of outcomes during
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …