The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

The hope of the rapid translation of'genes to drugs' has foundered on the reality that disease
biology is complex, and that drug development must be driven by insights into biological …

The gene's eye view of life, proposed in Richard Dawkins acclaimed bestseller The Selfish
Gene, sees living bodies as mere vehicles for the replication of genetic codes. But in The …

We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …

Most of the published quantitative models in biology are lost for the community because they
are either not made available or they are insufficiently characterized to allow them to be …

Advances in biotechnology and experimental techniques have lead to the elucidation of vast
amounts of biological data. Mathematical models provide a method of analysing this data; …

Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …

Epilepsy is a complex set of disorders that can involve many areas of the cortex, as well as
underlying deep-brain systems. The myriad manifestations of seizures, which can be as …

High fidelity (HF) mathematical models describing the generation of active force in the
cardiac muscle tissue typically feature a large number of state variables to capture the …

The kidney is faced with unique challenges for oxygen regulation, both because its function
requires that perfusion greatly exceeds that required to meet metabolic demand and …