[HTML][HTML] A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer
Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …
Long noncoding RNAs: recent insights into their role in male infertility and their potential as biomarkers and therapeutic targets
S Zhao, N Heng, B Weldegebriall Sahlu… - International Journal of …, 2021 - mdpi.com
Long noncoding RNAs (lncRNAs) are composed of nucleotides located in the nucleus and
cytoplasm; these are transcribed by RNA polymerase II and are greater than 200 nt in …
cytoplasm; these are transcribed by RNA polymerase II and are greater than 200 nt in …
[HTML][HTML] Harnessing the value of TCTP in breast cancer treatment resistance: an opportunity for personalized therapy
Early identification of breast cancer (BC) patients at a high risk of progression may aid in
therapeutic and prognostic aims. This is especially true for metastatic disease, which is …
therapeutic and prognostic aims. This is especially true for metastatic disease, which is …
Systematic understanding of anti-tumor mechanisms of tamarixetin through network and experimental analyses
Tamarixetin, a flavonoid derived from Quercetin, was shown to possess anti-cancer
properties in various types of cancer. However, the mechanism of action of this compound is …
properties in various types of cancer. However, the mechanism of action of this compound is …
[HTML][HTML] The lncRNA TPT1-AS1 promotes the survival of neuroendocrine prostate cancer cells by facilitating autophagy
PA Chen, PC Chang, WW Yeh, TY Hu… - American Journal of …, 2024 - ncbi.nlm.nih.gov
The lncRNA tumor protein translationally controlled 1-antisense RNA 1 (TPT1-AS1) is
known for its oncogenic role in various cancers, but its impact on the pathological …
known for its oncogenic role in various cancers, but its impact on the pathological …
A review of literature: role of long noncoding RNA TPT1-AS1 in human diseases
Y Li, F Li, Z Sun, J Li - Clinical and Translational Oncology, 2023 - Springer
Human diseases are multifactorial processes mainly driven by the intricate interactions of
genetic and environmental factors. Long noncoding RNAs (lncRNAs) represent a type of …
genetic and environmental factors. Long noncoding RNAs (lncRNAs) represent a type of …
[HTML][HTML] BUB1 Inhibition Overcomes Radio-and Chemoradiation Resistance in Lung Cancer
Simple Summary Elevated levels of the mitotic checkpoint kinase BUB1 are frequently
observed in most solid cancers, including lung cancer. High BUB1 expression is linked to …
observed in most solid cancers, including lung cancer. High BUB1 expression is linked to …
[HTML][HTML] Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome
D Thomas, M Palczewski, H Kuschman… - Research …, 2024 - ncbi.nlm.nih.gov
DNA methylation at cytosine bases of eukaryotic DNA (5-methylcytosine, 5mC) is a heritable
epigenetic mark that can regulate gene expression in health and disease. Enzymes that …
epigenetic mark that can regulate gene expression in health and disease. Enzymes that …
[HTML][HTML] BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer
S Sriramulu, S Thoidingjam… - … of Experimental & …, 2024 - jeccr.biomedcentral.com
Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype
often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective …
often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective …