Interindividual variability in genes encoding drug-metabolizing enzymes, transporters,
receptors, and human leukocyte antigens has a major impact on a patient's response to …

Psychotropic medication efficacy and tolerability are critical treatment issues faced by
individuals with psychiatric disorders and their healthcare providers. For some people, it can …

Background Higher frequencies of inflammatory adverse effects of clozapine have been
reported in Japan. As the international titration protocol for Asians has set slower dose …

In the past two decades, significant progress has been made in the development of
polygenic scores (PGSs). One specific application of PGSs is the development and potential …

Objective: The authors used longitudinal biobank data with up to 25 years of follow-up on
over 2,600 clozapine users to derive reliable estimates of the real-world burden of clozapine …

Background For psychotic disorders (ie schizophrenia), pharmacotherapy plays a key role in
controlling acute and long-term symptoms. To find the optimal individual dose and dosage …

Schizophrenia is a highly heritable, severe mental illness characterized by hallucinations,
delusions, social withdrawal, and cognitive dysfunction present in∼ 1% of populations …

Pharmacogenomics is the examination of how genetic variation influences drug metabolism
and response, in terms of both efficacy and safety. In cardiovascular disease, patient …

Persistent racial disparities in health outcomes have catalyzed legislative reforms and
heightened scientific focus recently. However, despite the well-documented properties of …

Blood concentrations of clozapine in Taiwanese patients appeared approximately 30–50%
higher than that from Caucasian patients, and women possessed a higher blood levels …