Purpose Insomnia is problematic for older adults. After behavioral modifications fail to show
adequate response, pharmacologic options are used. The pharmacokinetics of agents used …

Globally populations are ageing. By 2050, it is estimated that there will be two billion people
aged 60 years or over, of which 131 million are projected to be affected by dementia, while …

Accumulating evidence in mice models of accelerated senescence indicates a rescuing role
of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell …

The concept of mild cognitive impairment (MCI) as an intermediate state between normal
cognition and dementia entered into the vernacular of geriatric medicine more than 30 years …

There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid
deficiencies together, including the intimate relation between the metabolism of the two …

Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell)
and chromosome breaks. The likely mechanism is the deficient methylation of dUMP to …

Oxidative stress (OS) has been implicated in the pathophysiology of many neurological,
particularly neurodegenerative diseases. OS can cause cellular damage and subsequent …

Even today, as trendy diets and a weight-loss frenzy sweep the nation, two-thirds of adults
are still obese and children are being diagnosed with Type 2 diabetes, typically an “adult” …

Animal studies suggest that diets low in calories and rich in unsaturated fatty acids (UFA) are
beneficial for cognitive function in age. Here, we tested in a prospective interventional …

Background Antioxidants may protect the aging brain against oxidative damage associated
with pathological changes of Alzheimer disease (AD). Objective To examine the relationship …