The dsRNA protein kinase PKR: virus and cell control
The IFN-induced double-stranded RNA-dependent protein kinase (PKR) is one of the four
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …
Poxvirus pathogenesis
RM Buller, GJ Palumbo - Microbiological reviews, 1991 - Am Soc Microbiol
Poxviruses are a highly successful family of pathogens, with variola virus, the causative
agent of smallpox, being the most notable member. Poxviruses are unique among animal …
agent of smallpox, being the most notable member. Poxviruses are unique among animal …
[BOOK][B] The thalassaemia syndromes
DJ Weatherall, JB Clegg - 2008 - books.google.com
In the new edition of this successful and authoritative book, the thalassaemias are reviewed
in detail with respect to their clinical features, cellular pathology, molecular genetics …
in detail with respect to their clinical features, cellular pathology, molecular genetics …
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
E Meurs, K Chong, J Galabru, NSB Thomas, IM Kerr… - Cell, 1990 - cell.com
The double-stranded (ds) RNA-activated protein kinase from human cells is a 68 kd protein
(p68 kinase) induced by interferon. On activation by dsRNA in the presence of ATP, the …
(p68 kinase) induced by interferon. On activation by dsRNA in the presence of ATP, the …
[HTML][HTML] Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
GL Wang, GL Semenza - Journal of Biological Chemistry, 1993 - Elsevier
Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from
Hep3B cells cultured in 1% O2 but not in extracts from cells cultured in 20% O2. HIF-1 binds …
Hep3B cells cultured in 1% O2 but not in extracts from cells cultured in 20% O2. HIF-1 binds …
Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
TE Dever, L Feng, RC Wek, AM Cigan, TF Donahue… - Cell, 1992 - cell.com
We show that phosphorylation of the a subunit of eukaryotic translation initiation factor 2 (elF-
2) by the protein kinase GCN2 mediates translational control of the yeast transcriptional …
2) by the protein kinase GCN2 mediates translational control of the yeast transcriptional …
Evidence That Ternary Complex (eIF2-GTP-tRNAi Met)–Deficient Preinitiation Complexes Are Core Constituents of Mammalian Stress Granules
N Kedersha, S Chen, N Gilks, W Li… - Molecular biology of …, 2002 - Am Soc Cell Biol
Environmental stress-induced phosphorylation of eIF2α inhibits protein translation by
reducing the availability of eIF2-GTP-tRNAiMet, the ternary complex that joins initiator …
reducing the availability of eIF2-GTP-tRNAiMet, the ternary complex that joins initiator …
Interactions between double-stranded RNA regulators and the protein kinase DAI
L Manche, SR Green, C Schmedt… - Molecular and cellular …, 1992 - Taylor & Francis
The interferon-induced protein kinase DAI, the double-stranded RNA (dsRNA)-activated
inhibitor of translation, plays a key role in regulating protein synthesis in higher cells. Once …
inhibitor of translation, plays a key role in regulating protein synthesis in higher cells. Once …
pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.
IM Kerr, RE Brown - … of the National Academy of Sciences, 1978 - National Acad Sciences
A low molecular weight inhibitor of cell-free protein synthesis effective at subnanomolar
concentrations is formed on incubation of cytoplasmic extracts from interferon-treated cells …
concentrations is formed on incubation of cytoplasmic extracts from interferon-treated cells …
Mechanism and regulation of eukaryotic protein synthesis
WC Merrick - Microbiological reviews, 1992 - Am Soc Microbiol
This review presents a description of the numerous eukaryotic protein synthesis factors and
their apparent sequential utilization in the processes of initiation, elongation, and …
their apparent sequential utilization in the processes of initiation, elongation, and …